ABSTRACT
<p><b>OBJECTIVE</b>Study the risk factors that impact the effectiveness of mass hepatitis B vaccination, and try to amend them in the future.</p><p><b>METHOD</b>Based on the national surveillance of hepatitis B, all the 1734 of 1-15 years old children from Hebei Province were enrolled in the present study and they were divided into case and control group according to their sera HBsAg were positive or not.</p><p><b>RESULTS</b>Mother sera HBsAg positive and the hospital the children were born and earlier year of birth were risk factors.</p><p><b>CONCLUSION</b>The effectiveness of mass neonate hepatitis B vaccination has greatly improved and the future focus should be on finding pregnant HBsAg positive women, and encourage them to give birth in better hospitals, and at the mean time, try to make the neonate hepatitis B vaccination perfect, especially in country areas.</p>